Winter 2024 Undergrad Research Opportunities at UW
Undergraduate research for STEM students who code! Check out these 4 projects:
Sustainable, scalable bacterial cellulose nanoparticles for drug delivery to the brain
PI Name & Lab name: Prof. Elizabeth Nance Lab
Application deadline: January 26, 2024 by 10pm for priority review
Application link
Description: Sustainable nanomedicine is an emerging interdisciplinary field where biodegradable and biocompatible materials are of interest for therapeutic outcomes, specifically drug delivery to the brain. Sustainable formulation practices and the use of eco-friendly materials can make these therapeutics easily scalable and reproducible for commercial manufacturing. Bacterial cellulose nanoparticles (BCNPs) address these issues and have the potential to be a therapeutic to deliver drugs to the brain. In this project, the student will have the opportunity to prepare bacterial cellulose nanoparticles, experiment with drug loading techniques and assays, and apply therapeutics to ex vivo brain slice models. The student will investigate therapeutic effects and foundational information on BCNPs using confocal microscopy, ultraviolet spectroscopy, dynamic light scattering, and high-performance liquid chromatography characterization and analysis techniques.
Tuning the chemical and physical properties of bacterial cellulose nanoparticles for effective drug delivery
Many FDA approved materials in nanomedicine involve chemically intensive syntheses and are difficult to manufacture at the kilogram scale. We have recently developed bacterial cellulose nanoparticles as a therapeutic platform that can potentially be scaled to large quantities and be used to deliver drugs to the injured newborn brain. In this project, to demonstrate therapeutic effects of BCNPs, the student will incorporate curcumin, a naturally occurring small hydrophobic molecule with anti-inflammatory and antioxidant benefits, into the BCNPs, and potentially show reduced inflammation and brain injury in the neonatal hypoxic ischemic brain. The student will perform surface chemical modifications upon the BCNPs to incorporate the curcumin and investigate its therapeutic effects in healthy and unhealthy ex vivo brain slice models. By incorporating curcumin into BCNPs, the student will show the versatility of BCNPs in targeted therapeutics for treating critical diseases.
Accelerated development of nanomaterials through self-driving laboratories
PI Name & Lab name: Lilo Pozzo Lab
Application deadline: January 31, 2024
Description: Students with interests in nanomaterials, laboratory automation (robots), and coding, are invited to apply to work on the broad effort of accelerating materials discovery using artificial intelligence to create ‘self-driving laboratories’. Our laboratory works on the use of nanomaterials for solving broad problems in energy, healthcare, sustainability and for fundamental understanding of material behavior. ‘Self-driving laboratories’ aim to eliminate or reduce bottlenecks in research that hinder or slow progress to solving critical problems. Students will be expected to learn to work within diverse teams and to be willing to learn coding (Python), working on mechanical/electronic hardware equipment, data analysis and ‘wet’ laboratory work typical of chemistry and chemical engineering research projects.
How to Apply: Send expression of interest along with CV/Resume including academic information (major, year of study, GPA) to dpozzo(at)uw.edu. Good academic standing (e.g. as judged by courses and GPA) is required in order to ensure that research activities do not interfere with student’s ability to progress with academic success in their programs. Students will be expected to be able to commit to spending 6-9 hrs/week of research (2-3 credits per quarter) to be eligible to apply. Prof. Pozzo will reach out to candidates for continued discussions. Opportunities are limited by laboratory capacity.
Engineering Biology to Produce Chemicals and Materials
PI Name & Lab name: Carothers Research Group
Application deadline: March 15, 2024
Description: Our work aims to advance fundamental research into large-scale, bio-based chemical production that is not only greener, but also produces better alternatives to petrochemical-based products.
Application/instructions for expressing interest
The Origin of Life – Simulating the Evolution of Cells
PI Name & Lab name: Hugh Hillhouse
Description: Single cell organisms (like E. coli or S. saccharomyces) are complex self-governing chemical reactors. Understanding them is the future of chemical engineering. And, for the most part, we know of all the major molecular machinery that they are made of. We know the mechanisms of transcription, translation, regulation, and metabolism, and with advances in machine learning, we now know the approximate structure for all proteins! However, at the most basic level, we still do not understand how cells came to be. How did they emerge from their molecular constituents. This project will focus on answering that challenge with a new simulation modality developed by Hillhouse (similar to cellular automata). This project can accommodate 2 UGs. Previous programming experience is a pre-requisite. It can be experience in any programming language (Java, Python, C, Mathematica, etc.) The main thing is that the applicants understand how to program. You don’t need to be an expert, but you need to have some comfort with coding.
To Apply: Email Prof. Hillhouse and include: (1) your current CV, (2) unofficial transcript, (3) your coding experience, and (4) why you want to work on the project.